Archive | May 2017

Modeling Psychomotor Retardation using iPSCs from MCT8-Deficient Patients Indicates a Prominent Role for the Blood-Brain Barrier

Bhaskar Chanda Stem Cell Vatine et al. show that human iPSC-based modeling can pinpoint the origin of a neuronal disorder in the brain as a defect in transport of thyroid hormone across the blood-brain barrier, rather than in the neurons themselves.

from Cell Stem Cell http://ift.tt/2rcqaFh
via Bhaskar Chanda UHN

Advertisements

Deconstructing Olfactory Stem Cell Trajectories at Single-Cell Resolution

Bhaskar Chanda Stem Cell The olfactory epithelium is a site of active neurogenesis. Fletcher et al. combine single-cell transcriptomics and clonal lineage analysis to trace cell fates from the multipotent olfactory stem cell and identify multiple mechanisms controlling cell fate, including direct conversion of quiescent stem cells into support cells without cell division.

from Cell Stem Cell http://ift.tt/2qw440v
via Bhaskar Chanda UHN

Recruited Monocytes and Type 2 Immunity Promote Lung Regeneration following Pneumonectomy

Bhaskar Chanda Stem Cell Lechner et al. identify regenerative myeloid subpopulations, including recruited CCR2+ monocytes and Arginase1+ macrophages, during pneumonectomy-induced lung regeneration. Loss of recruited monocytes or Il4ra signaling impaired lung regeneration. The authors provide evidence that ILC2s and lung macrophages modulate the regenerative microenvironment to support alveolar epithelial stem cell proliferation and differentiation.

from Cell Stem Cell http://ift.tt/2r5MEoR
via Bhaskar Chanda UHN