An FAK-YAP-mTOR Signaling Axis Regulates Stem Cell-Based Tissue Renewal in Mice

Bhaskar Chanda Stem Cell Klein and colleagues show, using the mouse incisor as a model, that the transcriptional cofactors YAP and TAZ, components of the Hippo pathway, regulate stem cell-based tissue renewal by controlling the proliferation and differentiation of transit-amplifying cells in response to integrin/FAK signaling.

from Cell Stem Cell http://ift.tt/2oN1o9z
via Bhaskar Chanda UHN

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