Archive | April 2017

An FAK-YAP-mTOR Signaling Axis Regulates Stem Cell-Based Tissue Renewal in Mice

Bhaskar Chanda Stem Cell Klein and colleagues show, using the mouse incisor as a model, that the transcriptional cofactors YAP and TAZ, components of the Hippo pathway, regulate stem cell-based tissue renewal by controlling the proliferation and differentiation of transit-amplifying cells in response to integrin/FAK signaling.

from Cell Stem Cell http://ift.tt/2oN1o9z
via Bhaskar Chanda UHN

Gli1 Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target

Bhaskar Chanda Stem Cell Schneider and colleagues show that Gli1+ bone marrow mesenchymal stromal cells are an important source of fibrotic cells during bone marrow fibrosis and that targeting of Gli proteins with GANT61 holds promise for amelioration of this disease.

from Cell Stem Cell http://ift.tt/2p7I5eM
via Bhaskar Chanda UHN

Single-Cell RNA-Seq Analysis Maps Development of Human Germline Cells and Gonadal Niche Interactions

Bhaskar Chanda Stem Cell Li et al. interrogate the transcriptomes of over 2,000 fetal germ cells (FGCs) and their gonadal niche cells from male and female human embryos using single-cell RNA-seq analysis. They provide insights into the developmental trajectories and heterogeneity in FGCs over a wide range of developmental stages.

from Cell Stem Cell http://ift.tt/2oMXehZ
via Bhaskar Chanda UHN