H3K4 Methylation-Dependent Memory of Somatic Cell Identity Inhibits Reprogramming and Development of Nuclear Transfer Embryos

Bhaskar Chanda Stem Cell Hörmanseder et al. find that persistent memories of transcriptional activity in donor cell identity genes present a barrier to cell-fate reprogramming following nuclear transfer. They show that reducing H3K4 methylation in donor cells reduces transcriptional memory and improves the development of embryos derived by nuclear transfer.

from Cell Stem Cell http://ift.tt/2oCOew9
via Bhaskar Chanda UHN


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