DUSP9 Modulates DNA Hypomethylation in Female Mouse Pluripotent Stem Cells

Bhaskar Chanda Stem Cell The molecular equivalence of ESCs and EGCs remains incompletely understood. Choi et al. show that ESCs and EGCs are highly similar and that sex rather than cell type drives the transcriptional and epigenetic differences observed between individual cell lines. Female-specific hypomethylation is partially due to upregulation of the X-linked MAPK phosphatase DUSP9.

from Cell Stem Cell http://ift.tt/2oltvOb
via Bhaskar Chanda UHN


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