Targeting BMI1 Cancer Stem Cells Overcomes Chemoresistance and Inhibits Metastases in Squamous Cell Carcinoma

Bhaskar Chanda Stem Cell Chen et al. show that BMI1+ CSCs drive invasive growth and cervical lymph node metastasis in squamous cell carcinoma. BMI1+ CSCs have increased AP-1 activity and are chemotherapy resistant, and combination therapy that targets BMI1+ CSCs and the tumor bulk yields better outcomes and effectively eliminates metastasis.

from Cell Stem Cell http://ift.tt/2mKOImx
via Bhaskar Chanda UHN

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