Mex3a Marks a Slowly Dividing Subpopulation of Lgr5+ Intestinal Stem Cells

Bhaskar Chanda Stem Cell Lgr5+ intestinal stem cells are considered to be a homogeneous and rapidly proliferating population. Barriga et al. show that the RNA binding protein Mex3a defines a subset of slowly proliferating Lgr5+ cells that contribute to all intestinal lineages with slow kinetics, are resistant to chemotherapy, and support intestinal regeneration.

from Cell Stem Cell
via Bhaskar Chanda UHN


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