Genome Editing in hPSCs Reveals Haploinsufficiency and a Genetic Interaction with in Human Pancreatic Development

Bhaskar Chanda Stem Cell Huangfu, Chen, and colleagues model human pancreatic disease by stepwise differentiation of genetically modified hPSCs to characterize the phenotypic effects of GATA6 haploinsufficiency not evident in mouse models and its genetic interaction with GATA4.

from Cell Stem Cell http://ift.tt/2kMvDNG
via Bhaskar Chanda UHN

Advertisements

Tags: , , , , , , ,

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

%d bloggers like this: