Genome Editing in hPSCs Reveals Haploinsufficiency and a Genetic Interaction with in Human Pancreatic Development

Bhaskar Chanda Stem Cell Huangfu, Chen, and colleagues model human pancreatic disease by stepwise differentiation of genetically modified hPSCs to characterize the phenotypic effects of GATA6 haploinsufficiency not evident in mouse models and its genetic interaction with GATA4.

from Cell Stem Cell
via Bhaskar Chanda UHN


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