Human iPSC-Derived Cerebral Organoids Model Cellular Features of Lissencephaly and Reveal Prolonged Mitosis of Outer Radial Glia

Bhaskar Chanda Stem Cell Bershteyn and colleagues show that cerebral organoid modeling of lissencephaly using iPSCs derived from Miller-Dieker syndrome patients can characterize cellular and neurodevelopmental disease phenotypes and identify a mitotic defect in outer radial glia, a cell type that is particularly important for human cortical development.

from Cell Stem Cell
via Bhaskar Chanda UHN


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