Patient-Specific iPSC-Derived Endothelial Cells Uncover Pathways that Protect against Pulmonary Hypertension in BMPR2 Mutation Carriers

Bhaskar Chanda Stem Cell As part of the NHLBI NextGen consortium, Gu et al. report protective mechanisms of potential therapeutic significance in unaffected BMPR2 mutation carrier (UMC) iPSC-derived endothelial cells (iPSC-ECs) versus iPSC-ECs from family members with pulmonary arterial hypertension (FPAH). Their findings about changes in specific regulators could inform future therapy development.

from Cell Stem Cell
via Bhaskar Chanda UHN


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