Human Naive Pluripotent Stem Cells Model X Chromosome Dampening and X Inactivation

Bhaskar Chanda Stem Cell Plath and colleagues study the epigenetic state of the X chromosomes in naive female hPSCs and discover that it closely, but not perfectly, resembles the X chromosome pattern of pre-implantation blastocysts. The naive state enables de novo X inactivation upon differentiation and thus can provide a model for studying X chromosome regulation in human cells.

from Cell Stem Cell
via Bhaskar Chanda UHN


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