PHB Associates with the HIRA Complex to Control an Epigenetic-Metabolic Circuit in Human ESCs

Bhaskar Chanda Stem Cell Based on a genome-wide siRNA screen, Jin and colleagues identify PHB as a key factor in hESC self-renewal. PHB forms a complex with HIRA to regulate histone H3.3 deposition and expression of a range of genes, including some related to metabolic circuitry.

from Cell Stem Cell http://ift.tt/2gGcDNL
via Bhaskar Chanda UHN

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