Induced Quiescence of Lgr5+ Stem Cells in Intestinal Organoids Enables Differentiation of Hormone-Producing Enteroendocrine Cells

Bhaskar Chanda Stem Cell Basak et al. identify signals to generate rare enteroendocrine cells (EECs) at high purity through manipulation of intestinal stem cell quiescence. Single-cell sequencing reveals a high level of heterogeneity in hormonal production, which is influenced by the regional identity of the intestinal organoid cultures.

from Cell Stem Cell
via Bhaskar Chanda UHN


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