The p53 Family Coordinates Wnt and Nodal Inputs in Mesendodermal Differentiation of Embryonic Stem Cells

Bhaskar Chanda Stem Cell Massagué and colleagues show that the p53/63/73 family is essential for mesendoderm specification in embryonic stem cells. The p53 family transcriptionally activates the Wnt pathway in human and mouse ESCs to coordinate Wnt-Tcf and nodal-Smad inputs for mesendodermal differentiation of ESCs in vitro and in the embryo.

from Cell Stem Cell
via Bhaskar Chanda UHN


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