Cardiac Fibroblasts Adopt Osteogenic Fates and Can Be Targeted to Attenuate Pathological Heart Calcification
Bhaskar Chanda Stem Cell Pillai et al. demonstrate that cardiac fibroblasts adopt bone-forming cell fates and induce ectopic calcification. ENPP1, an enzyme that regulates bone mineralization, is induced in cardiac fibroblasts after injury. Administration of ENPP1 inhibitors or inhibitors of bone mineralization significantly decreased pathologic cardiac calcification and augmented cardiac function.