A Single-Cell Roadmap of Lineage Bifurcation in Human ESC Models of Embryonic Brain Development

Bhaskar Chanda Stem Cell Yao et al. perform single-cell RNA-seq during neural differentiation of hESCs. They identify many classes of neural progenitors and neurons that map to early human brain cells, computationally infer and experimentally confirm lineage relationships between them, and show that Wnt signaling influences the bifurcation between forebrain and mid/hindbrain lineages in vitro.

from Cell Stem Cell http://ift.tt/2ezIS3g
via Bhaskar Chanda UHN


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