DNA Damage-Induced HSPC Malfunction Depends on ROS Accumulation Downstream of IFN-1 Signaling and Bid Mobilization

Bhaskar Chanda Stem Cell Tasdogan et al. identify toxic levels of reactive oxygen species (ROS) as major culprit underlying HSPC malfunction in a mouse mutant with defective DNA repair. They further demonstrate that high ROS levels in HSPCs are dependent on DNA damage-associated IFN-1 signaling and the Bcl-2 homolog Bid.

from Cell Stem Cell http://ift.tt/2cu1504
via Bhaskar Chanda UHN

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