Functional Impairment in Miro Degradation and Mitophagy Is a Shared Feature in Familial and Sporadic Parkinson’s Disease

Bhaskar Chanda Stem Cell Using iPSC-derived neurons and other models, Hsieh et al. uncover a defect in clearance of damaged mitochondria in Parkinson’s disease. They show that in mutant cells, the mitochondrial outer membrane protein Miro is stabilized and remains on damaged mitochondria for longer than normal, prolonging active transport and inhibiting mitochondrial degradation.

from Cell Stem Cell
via Bhaskar Chanda UHN


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