Adventitial MSC-like Cells Are Progenitors of Vascular Smooth Muscle Cells and Drive Vascular Calcification in Chronic Kidney Disease

Bhaskar Chanda Stem Cell Kramann et al. show that Gli1+ MSC-like cells that reside in the vascular wall differentiate into osteoblast-like cells after injury and make a major contribution to calcification. Ablation of these cells before injury eliminates calcification and therefore suggests that they could be a target for therapeutic intervention.

from Cell Stem Cell
via Bhaskar Chanda UHN


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