MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis

Bhaskar Chanda Stem Cell Aranda-Orgilles et al. show in vivo a cell-autonomous requirement of MED12 in the maintenance of hematopoietic stem cell function independent of CYCLIN C/CDK8. MED12 cooperates with P300 to preserve enhancer activity, and loss of MED12 causes H3K27Ac depletion at enhancers of essential HSC genes and failure of hematopoietic-specific transcriptional programs.

from Cell Stem Cell
via Bhaskar Chanda UHN


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