Multipotency of Adult Hippocampal NSCs In Vivo Is Restricted by Drosha/NFIB

Bhaskar Chanda Stem Cell Rolando et al. investigated the function of the RNaseIII Drosha in the regulation of adult hippocampal stem cell maintenance and differentiation. They found that Drosha directly inhibits the expression of the transcription factor NFIB through a miRNA-independent mechanism, thereby permitting neurogenesis and preventing oligodendrocyte fate commitment.

from Cell Stem Cell
via Bhaskar Chanda UHN


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