Enhancing a Wnt-Telomere Feedback Loop Restores Intestinal Stem Cell Function in a Human Organotypic Model of Dyskeratosis Congenita

Bhaskar Chanda Stem Cell Using a human induced pluripotent stem cell-derived dyskeratosis congenita (DC) organotypic model, Woo and colleagues show that telomere shortening triggers abrogation of canonical Wnt signaling, resulting in defects in intestinal stem cell function. Restoring telomere capping and enhancing Wnt signaling can restore the Wnt-telomere feedback loop and rescue DC-associated intestinal dysfunction.

from Cell Stem Cell http://ift.tt/2bpiCbO
via Bhaskar Chanda UHN


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