Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy

Bhaskar Chanda Stem Cell Liang et al. show that after infection of human fetal neural stem cells, the ZIKV proteins NS4A and NS4B inhibit the Akt-mTOR signaling pathway, disrupting neurogenesis and inducing autophagy. Their study therefore identifies candidate molecular determinants of ZIKV pathogenesis and highlights potential targets for therapeutic intervention.

from Cell Stem Cell http://ift.tt/2baLTH1
via Bhaskar Chanda UHN

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