Targeted Epigenetic Remodeling of Endogenous Loci by CRISPR/Cas9-Based Transcriptional Activators Directly Converts Fibroblasts to Neuronal Cells

Bhaskar Chanda Stem Cell Black et al. show that reprogramming of fibroblasts to induced neurons via CRISPR/Cas9-based activation of endogenous neurogenic genes leads to rapid epigenetic remodeling at the targeted endogenous loci and sustained gene expression throughout the reprogramming process.

from Cell Stem Cell http://ift.tt/2baLPar
via Bhaskar Chanda UHN

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