Proximity-Based Differential Single-Cell Analysis of the Niche to Identify Stem/Progenitor Cell Regulators

Bhaskar Chanda Stem Cell Silberstein et al. describe an approach combining micro-anatomical proximity between stem/progenitor cells and stromal cells and differential single-cell gene expression to identify niche cells and factors regulating HSPC function. With adaptation, this approach could be applied to discover regulatory niche factors for other stem cell populations.

from Cell Stem Cell
via Bhaskar Chanda UHN


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