Tissue Mechanics Orchestrate Wnt-Dependent Human Embryonic Stem Cell Differentiation

Bhaskar Chanda Stem Cell Przybyla et al. describe how properties of the extracellular matrix can direct fate specification in hESCs. They show that mechanical forces resulting from differential matrix stiffness translate via junctional organization, Src, and β-catenin into transcriptional responses that drive mesodermal differentiation.

from Cell Stem Cell http://ift.tt/29Z1YdV
via Bhaskar Chanda UHN

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