The Central Nervous System Regulates Embryonic HSPC Production via Stress-Responsive Glucocorticoid Receptor Signaling

Bhaskar Chanda Stem Cell In this study, North and colleagues uncover serotonin-stimulated central regulation of hematopoietic stem cell production during embryonic development, mediated by the stress-responsive hypothalamic-pituitary-adrenal/interrenal (HPA/I) axis and glucocorticoid receptor. Significantly, the hypoxic stress sensor Hif1α is a physiologic initiator of CNS-derived serotonin synthesis and central feedback regulation of embryonic HSC numbers.

from Cell Stem Cell
via Bhaskar Chanda UHN


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