Ectopic miR-125a Expression Induces Long-Term Repopulating Stem Cell Capacity in Mouse and Human Hematopoietic Progenitors
Bhaskar Chanda Stem Cell Wojtowicz et al. report that enforced expression of miR-125a confers enhanced long-term self-renewal potential to multipotent hematopoietic progenitors (MPPs). Quantitative proteomics reveals a miR-125a target network that normally functions to restrain self-renewal in more committed progenitors. These results suggest that enhanced MPPs may be used to augment limited HSC sources.