Dedifferentiated Schwann Cell Precursors Secreting Paracrine Factors Are Required for Regeneration of the Mammalian Digit Tip

Bhaskar Chanda Stem Cell Johnston et al. show that, during regeneration of the mouse digit tip, nerve-associated Schwann cell precursors dedifferentiate and move into the injured tissue, where they secrete paracrine factors, including oncostatin M and PDGF-AA, to promote mesenchymal cell proliferation, expansion of the blastema, and regeneration.

from Cell Stem Cell
via Bhaskar Chanda UHN


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