p38α Activates Purine Metabolism to Initiate Hematopoietic Stem/Progenitor Cell Cycling in Response to Stress

Bhaskar Chanda Stem Cell Karigane et al. characterize a regulatory pathway involved in hematopoietic stem cell stress responses. They show that p38α, which is activated by hematopoietic stress, promotes purine metabolism through Mitf-mediated Impdh2 upregulation. Activated purine metabolism promotes hematopoietic stem/progenitor cell cycling and maintains repopulation capacity after transplantation.

from Cell Stem Cell http://ift.tt/28Ry0x3
via Bhaskar Chanda UHN

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