p38α Activates Purine Metabolism to Initiate Hematopoietic Stem/Progenitor Cell Cycling in Response to Stress
Bhaskar Chanda Stem Cell Karigane et al. characterize a regulatory pathway involved in hematopoietic stem cell stress responses. They show that p38α, which is activated by hematopoietic stress, promotes purine metabolism through Mitf-mediated Impdh2 upregulation. Activated purine metabolism promotes hematopoietic stem/progenitor cell cycling and maintains repopulation capacity after transplantation.