Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells

Bhaskar Chanda Stem Cell Mou et al. show that small-molecule-mediated SMAD signaling inhibition allows prolonged feeder-free culture of diverse functional epithelial basal stem cells in a 2D format. This methodology provides a facile patient-specific epithelial disease modeling platform, as shown by the expansion of airway epithelium from non-invasively obtained specimens from cystic fibrosis patients.

from Cell Stem Cell http://ift.tt/1UxXgqW
via Bhaskar Chanda UHN

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