Persistent Activation of NF-κB in BRCA1-Deficient Mammary Progenitors Drives Aberrant Proliferation and Accumulation of DNA Damage

Bhaskar Chanda Stem Cell BRCA1 mutations increase the risk for breast cancer and have been linked with hormone-independent abnormal proliferation of mammary luminal progenitors. In this study, Sau et al. find that DNA-damage-induced NF-κB activation in BRCA1-deficient luminal progenitors is a cellular mechanism required for hormone-uncoupled proliferation, increasing the risk of genomic instability and transformation.

from Cell Stem Cell
via Bhaskar Chanda UHN


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