Mitochondrial Dynamics Impacts Stem Cell Identity and Fate Decisions by Regulating a Nuclear Transcriptional Program
Bhaskar Chanda Stem Cell Khacho et al. report that mitochondrial dynamics regulates neural stem cell fate during development and in the adult mouse brain. Using acute loss-of-function approaches to uncouple mitochondrial bioenergetics from the fission/fusion machinery, they find that the latter independently regulates ROS levels upstream of NRF2. Thus, defects in mechanisms that maintain the pool of mitochondria also impair neural stem cell function, which has important implications for aging and neurodegenerative diseases.