Genetic Drift Can Compromise Mitochondrial Replacement by Nuclear Transfer in Human Oocytes

Bhaskar Chanda Stem Cell Yamada et al. show, using human cells, that even small amounts of mtDNA carried over during nuclear transfer for mitochondrial replacement can lead to mtDNA genotype reversion. This situation would need to be avoided for clinical application and stable prevention of mtDNA diseases.

from Cell Stem Cell
via Bhaskar Chanda UHN


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