Zika Virus Disrupts Neural Progenitor Development and Leads to Microcephaly in Mice
Bhaskar Chanda Stem Cell The suspected link between Zika virus (ZIKV) infection and microcephaly has raised urgent global alarm. However, there is so far no direct evidence for ZIKV infection impacting brain development. In this study, Li, Xu, and colleagues show that ZIKV replicates efficiently in the mouse embryonic brain by mainly targeting neural progenitor cells. They also show that infected brains are smaller with enlarged ventricles and a thinner cortex, consistent with a microcephalic phenotype.