Genome Editing of Lineage Determinants in Human Pluripotent Stem Cells Reveals Mechanisms of Pancreatic Development and Diabetes

Bhaskar Chanda Stem Cell By combining genome editing and hPSC-directed differentiation, Zhu and colleagues systematically examined eight transcription factors for their roles in pancreatic development. Their study not only verified conserved gene requirements between mice and humans but also revealed a number of previously unsuspected and potentially human-specific features.

from Cell Stem Cell
via Bhaskar Chanda UHN


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