Chemical Control of Grafted Human PSC-Derived Neurons in a Mouse Model of Parkinson’s Disease

Bhaskar Chanda Stem Cell Chen et al. show that motor function in PD mice can be reversed or enhanced following transplantation of dopamine neurons differentiated from hPSCs engineered to express DREADDs. Administering CNO noninvasively and reversibly modulates neuronal graft function, highlighting the potential to exogenously control and refine therapeutic outcomes following cell transplantation.

from Cell Stem Cell
via Bhaskar Chanda UHN


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