TGF-β Inhibition Rescues Hematopoietic Stem Cell Defects and Bone Marrow Failure in Fanconi Anemia

Bhaskar Chanda Stem Cell Zhang and colleagues identify hyperactive TGF-β signaling as a mechanism of bone marrow failure in Fanconi anemia (FA). They show that inhibition of TGF-β signaling promotes survival of FA HSPCs, restoring their function. These studies lay the foundation for testing TGF-β inhibitors as therapeutic agents for FA.

from Cell Stem Cell
via Bhaskar Chanda UHN


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