Leptin Receptor Promotes Adipogenesis and Reduces Osteogenesis by Regulating Mesenchymal Stromal Cells in Adult Bone Marrow

Bhaskar Chanda Stem Cell A fundamental question concerns how stem cells are regulated by nutrition and systemic energy homeostasis. Morrison and colleagues demonstrate that leptin receptor acts within skeletal stem cells in the bone marrow as a sensor of systemic energy homeostasis, promoting adipogenesis and inhibiting osteogenesis in response to diet and adiposity.

from Cell Stem Cell http://ift.tt/1MEuaim
via Bhaskar Chanda UHN

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