Lineage Reprogramming of Fibroblasts into Proliferative Induced Cardiac Progenitor Cells by Defined Factors
Bhaskar Chanda Stem Cell Lalit et al. report that a combination of cardiac factors and signaling molecules reprogram adult mouse fibroblasts into expandable induced cardiac progenitor cells (iCPCs). iCPCs are multipotent and can differentiate into cardiomyocytes, smooth muscle, and endothelial cells. Moreover, iCPCs generate myocardium when injected into the embryonic and adult post-MI mouse heart.