Replacement of Lost Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters
Bhaskar Chanda Stem Cell In this article, Tetteh et al. show that enterocyte-lineage progenitors can become stem cells during intestinal regeneration. Additionally, these cells generate Paneth-like cells and turn on genes that promote recovery from injury. In sum, “stemness” in intestinal crypts is not “hard-wired;” many progenitors can regain stemness upon loss of the actual stem cells.