Archive | January 2016

Bile Acids Protect Expanding Hematopoietic Stem Cells from Unfolded Protein Stress in Fetal Liver

Bhaskar Chanda Stem Cell Sigurdsson et al. report that bile acids unexpectedly function as chemical chaperones that are critically required for alleviating ER stress during expansion of fetal hematopoietic stem cells.

from Cell Stem Cell http://ift.tt/1PIoEle
via Bhaskar Chanda UHN

Replacement of Lost Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters

Bhaskar Chanda Stem Cell In this article, Tetteh et al. show that enterocyte-lineage progenitors can become stem cells during intestinal regeneration. Additionally, these cells generate Paneth-like cells and turn on genes that promote recovery from injury. In sum, “stemness” in intestinal crypts is not “hard-wired;” many progenitors can regain stemness upon loss of the actual stem cells.

from Cell Stem Cell http://ift.tt/1NDt6u8
via Bhaskar Chanda UHN