Stepwise Clearance of Repressive Roadblocks Drives Cardiac Induction in Human ESCs

Bhaskar Chanda Stem Cell In this article, Greber and colleagues reveal signaling principles that underlie directed differentiation of human ESCs into cardiomyocytes. The authors show that BMP and WNT pathways promote cardiac induction through sequential and dose-dependent suppression of repressive regulators that otherwise drive differentiation into alternate lineages.

from Cell Stem Cell
via Bhaskar Chanda UHN


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