Identification and Successful Negotiation of a Metabolic Checkpoint in Direct Neuronal Reprogramming

Bhaskar Chanda Stem Cell By imaging cell fate conversion over time, Gascón, Murenu, and colleagues find that high levels of oxidative stress prevent successful direct neuronal reprogramming, instead causing extensive cell death. They identify inhibitors of ferroptosis, antioxidants, and Bcl-2 as key metabolic agents in improving generation of iNs from a range of somatic cells and in vivo after brain injury.

from Cell Stem Cell
via Bhaskar Chanda UHN


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