Human-Mouse Chimerism Validates Human Stem Cell Pluripotency

Bhaskar Chanda Stem Cell Mascetti and Pedersen show that stage-matching of human pluripotent cells to gastrula-stage mouse embryos overcomes barriers to chimerism, allowing efficient interspecies chimera formation with widespread cell dispersal and tissue-specific differentiation. These findings provide in vivo functional validation of hPSC pluripotency.

from Cell Stem Cell
via Bhaskar Chanda UHN


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