Regulation of Skeletal Muscle Stem Cell Quiescence by Suv4-20h1-Dependent Facultative Heterochromatin Formation

Bhaskar Chanda Stem Cell Boonsanay et al. show that Suv4-20h1 dynamically regulates muscle stem cell quiescence by regulating facultative heterochromatin formation. Disruption of Suv4-20h1 leads to activation of the MyoD locus and persistent stem cell activation, eventually leading to stem cell depletion and loss of skeletal muscle regeneration.

from Cell Stem Cell
via Bhaskar Chanda UHN


Tags: , , , , , , ,

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

%d bloggers like this: