Regulation of Skeletal Muscle Stem Cell Quiescence by Suv4-20h1-Dependent Facultative Heterochromatin Formation

Bhaskar Chanda Stem Cell Boonsanay et al. show that Suv4-20h1 dynamically regulates muscle stem cell quiescence by regulating facultative heterochromatin formation. Disruption of Suv4-20h1 leads to activation of the MyoD locus and persistent stem cell activation, eventually leading to stem cell depletion and loss of skeletal muscle regeneration.

from Cell Stem Cell http://ift.tt/21F1oYK
via Bhaskar Chanda UHN

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