Genomic Instability in Human Pluripotent Stem Cells Arises from Replicative Stress and Chromosome Condensation Defects

Bhaskar Chanda Stem Cell Lamm et al. identify a mechanism leading to the ongoing chromosomal instability observed in hPSCs harboring recurrent aneuplodies and which may induce instability in diploid hPSCs. They find that decreased SRF levels cause cytoskeletal impairments that perturb DNA replication and chromosomal condensation, resulting in chromosome segregation errors and genomic instability.

from Cell Stem Cell
via Bhaskar Chanda UHN


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