The Locus Preserves LT-HSC Function by Inhibiting the PI3K-mTOR Pathway to Restrict Mitochondrial Metabolism
Bhaskar Chanda Stem Cell Qian and colleagues show that ncRNAs expressed from the imprinted locus Dlk1-Gtl2 maintain fetal liver and adult LT-HSCs through multiplexed inhibition of PI3K-mTOR signaling that in turn keeps mitochondrial biogenesis and metabolic activity in check.
Bhaskar Chanda Stem Cell Steinbeck and colleagues use optogenetics in human spinal motorneurons to establish a functional neuromuscular junction with co-cultured skeletal muscle in vitro and then apply this system for phenotypic analysis of an autoimmune disease.
Phosphorylation of eIF2α Is a Translational Control Mechanism Regulating Muscle Stem Cell Quiescence and Self-Renewal
Bhaskar Chanda Stem Cell Adult stem cells require regulated protein synthesis. Crist and colleagues show that translational control by eIF2α regulates the activity of the skeletal muscle stem cell. Pharmacological manipulation of this pathway maintains the regenerative capacity of muscle stem cells that is normally lost after culture ex vivo.