Archive | November 2015

The Locus Preserves LT-HSC Function by Inhibiting the PI3K-mTOR Pathway to Restrict Mitochondrial Metabolism

Bhaskar Chanda Stem Cell Qian and colleagues show that ncRNAs expressed from the imprinted locus Dlk1-Gtl2 maintain fetal liver and adult LT-HSCs through multiplexed inhibition of PI3K-mTOR signaling that in turn keeps mitochondrial biogenesis and metabolic activity in check.

from Cell Stem Cell http://ift.tt/1P9yFHr
via Bhaskar Chanda UHN

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Functional Connectivity under Optogenetic Control Allows Modeling of Human Neuromuscular Disease

Bhaskar Chanda Stem Cell Steinbeck and colleagues use optogenetics in human spinal motorneurons to establish a functional neuromuscular junction with co-cultured skeletal muscle in vitro and then apply this system for phenotypic analysis of an autoimmune disease.

from Cell Stem Cell http://ift.tt/1iFG9mH
via Bhaskar Chanda UHN

Phosphorylation of eIF2α Is a Translational Control Mechanism Regulating Muscle Stem Cell Quiescence and Self-Renewal

Bhaskar Chanda Stem Cell Adult stem cells require regulated protein synthesis. Crist and colleagues show that translational control by eIF2α regulates the activity of the skeletal muscle stem cell. Pharmacological manipulation of this pathway maintains the regenerative capacity of muscle stem cells that is normally lost after culture ex vivo.

from Cell Stem Cell http://ift.tt/1PpYqBE
via Bhaskar Chanda UHN