Rapid Conversion of Fibroblasts into Functional Forebrain GABAergic Interneurons by Direct Genetic Reprogramming

Bhaskar Chanda Stem Cell Colasante et al. identify a combination of five transcription factors that convert mouse and human fibroblasts into induced GABAergic telencephalic interneurons (iGABA-INs), which are functionally similar to bona fide GABAergic INs. Upon transplantation, iGABA-INs functionally integrate into host neuronal networks and inhibit excitatory neurons in the host hippocampus.

from Cell Stem Cell http://ift.tt/20d9Ygz
via Bhaskar Chanda UHN


Tags: , , , , , , ,

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

%d bloggers like this: