Rapid Conversion of Fibroblasts into Functional Forebrain GABAergic Interneurons by Direct Genetic Reprogramming

Bhaskar Chanda Stem Cell Colasante et al. identify a combination of five transcription factors that convert mouse and human fibroblasts into induced GABAergic telencephalic interneurons (iGABA-INs), which are functionally similar to bona fide GABAergic INs. Upon transplantation, iGABA-INs functionally integrate into host neuronal networks and inhibit excitatory neurons in the host hippocampus.

from Cell Stem Cell http://ift.tt/20d9Ygz
via Bhaskar Chanda UHN

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