Polycomb Complex PRC1 Preserves Intestinal Stem Cell Identity by Sustaining Wnt/β-Catenin Transcriptional Activity

Bhaskar Chanda Stem Cell Chiacchiera et al. show that PRC1 activity is essential to maintain integrity of the intestinal epithelium during homeostasis and in cancer. Mechanistically, PRC1 represses non-lineage-specific transcription factors that in turn directly affect β-catenin/Tcf transcriptional activity and Wnt-dependent intestinal stem cell self-renewal.

from Cell Stem Cell http://ift.tt/1Wl2PWS
via Bhaskar Chanda UHN

Advertisements

Tags: , , , , , , ,

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

%d bloggers like this: