Polycomb Complex PRC1 Preserves Intestinal Stem Cell Identity by Sustaining Wnt/β-Catenin Transcriptional Activity

Bhaskar Chanda Stem Cell Chiacchiera et al. show that PRC1 activity is essential to maintain integrity of the intestinal epithelium during homeostasis and in cancer. Mechanistically, PRC1 represses non-lineage-specific transcription factors that in turn directly affect β-catenin/Tcf transcriptional activity and Wnt-dependent intestinal stem cell self-renewal.

from Cell Stem Cell http://ift.tt/1Wl2PWS
via Bhaskar Chanda UHN


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